![]() ![]() ![]() ![]() Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. Involved in promoting endothelial cell motility and angiogenesis. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-V/beta-1 is a receptor for vitronectin. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-1 is a receptor for VCAM1. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. ![]()
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